Jacek Witold Morzycki;Lucie Hoffmannova;Miroslav Strnad;Jana Oklestkova;Agnieszka Wojtkielewicz
发明人:
Jacek Witold Morzycki,Agnieszka Wojtkielewicz,Jana Oklestkova,Lucie Hoffmannova,Miroslav Strnad
申请号：
US13147771
公开号：
US08552161B2
申请日:
2010.02.08
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention relates to novel saponin compounds of formula II wherein MBz denotes p-methoxybenzoyl, and R is selected from the group comprising C6-10 aryl, C6-10 aryl-C1-4 alkyl-, C1-18 alkanoyl, C3-18 alkenyl, C6-10 aryl-C(O)—, C6-10 aryl-C1-4 alkyl-C(O)—, wherein each of the groups can optionally be substituted. These compounds possess a selective cytostatic activity, useful, e.g., in the treatment of proliferative diseases. The invention further relates to methods of preparation of the novel compounds and to a pharmaceutical composition containing these compounds.
