An object of this invention is to provide the formulation which is excellent in functionality, such as transdermal absorbability and solvent dispersibility of the active ingredient obtained easily. In the present invention, a liquid in which a good water-soluble solute is dissolved in water and a liquid in which an active substance is dissolved in a solvent are mixed through a different flow path immediately before spraying, and then the liquid fine particles are added by a pressurized gas. Sprayed in the state of, and can be obtained by vaporizing and removing the water and the solvent, dispersed in the microparticles containing the good water-soluble solute, and / or present on the surface of the microparticles. The present invention relates to nanofunctional particles containing the active substance.本発明は、簡便に得られる活性成分の経皮吸収性や溶媒分散性などの機能性に優れている製剤を提供することを目的とする。 本発明は、良水溶性溶質を水に溶解した液体と、活性物質を溶媒に溶解した液体とを、それぞれ別の流路を経て、噴霧直前に混合をした後に、加圧気体によって、液状微粒子の状態で噴霧し、前記水と前記溶媒とを気化し除去することにより得られうる、前記良水溶性溶質を含むマイクロ粒子の中で分散する、及び／又は、前記マイクロ粒子の表面に存在する、前記活性物質を含むナノ機能性粒子に関する。
