The purpose of the present invention is to provide an easily obtained formulation having exceptional functionality such as solvent dispersibility and percutaneous absorptivity of an active ingredient. The present invention pertains to functional nanoparticles including an active substance, the functional nanoparticles being dispersed in microparticles that include a readily water-soluble solute, and/or being present on the surface of the microparticles. The functional nanoparticles can be obtained by mixing immediately before spraying a liquid in which a readily water-soluble solute is dissolved in water and a liquid in which the active substance is dissolved in a solvent via separate flow paths, subsequently spraying the mixed liquid while the same is in a liquid-fine-particle state by using a pressurized gas, and removing the water and solvent through vaporization.本發明之目的在於提供一種可簡便地得到且活性成分的經皮吸收性或溶劑分散性等之機能性優異之製劑。本發明係關於一種含有活性物質之奈米機能性粒子，其係於含有良水溶性溶質之微粒子中分散及/或存在於前述微粒子的表面，在將使前述良水溶性溶質溶解於水之液體、與使前述活性物質溶解於溶劑之液體，分別經由不同流路，於噴霧不久前混合後，藉由加壓氣體以液狀微粒子之狀態噴霧，並藉由將前述水及前述溶劑氣化去除而得到。
