I-CREI HOMING ENDONUCLEASE VARIANTS HAVING NOVEL CLEAVAGE SPECIFICITY AND USE THEREOF

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专利权人:

Cellectis

发明人:

Frederic Paques

申请号：

US13744068

公开号：

US20130209437A1

申请日:

2013.01.17

申请国别(地区):

US

年份:

2013

代理人:

摘要：

A method for engineering I-CreI homing endonuclease variants able to cleave mutant I-CreI sites having variation in positions ±8 to ±10. A I-CreI homing endonuclease variant obtainable by said method, a vector encoding said variant, a cell, an animal or a plant modified by said vector. Use of said I-CreI endonuclease variant and derived products for genetic engineering, genome therapy and antiviral therapy.

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