Engineering of immunoglobulin domains

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专利权人:

National Research Council of Canada

发明人:

Kim, Dae Young,Tanha, Jamshid

申请号：

AU2012211011

公开号：

AU2012211011A1

申请日:

2012.01.27

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present invention provides a single domain antibody (sdAb) scaffold comprising one or more than one non-canonical disulfide bond in the framework region (FR). The one or more than one non-canonical disulfide bond may be formed between cysteines introduced by mutations in FR2 and FR3. In the case where the sdAb scaffold is a V

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