MANUFACTURING AND ENGINEERING OF DNASE ENZYMES FOR THERAPY

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专利权人:

Inc.;Neutrolis

发明人:

Tobias A. FUCHS,Abdul HAKKIM R.

申请号：

US16697502

公开号：

US20200115690A1

申请日:

2019.11.27

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present disclosure provides engineered human extracellular DNASE proteins (e.g., variants of DNASE1 (D1), DNASE1-LIKE 1 (D1L1), DNASE1-LIKE 2 (D1L2), DNASE1-LIKE 3 Isoform 1 (D1L3), DNASE1-LIKE 3 Isoform 2 (D1L3-2), DNASE2A (D2A), and DNASE2B (D2B)) that are useful for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and/or release. In accordance with the invention, the DNase variant has advantages for therapy and/or large-scale manufacturing.

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