SUBSTITUTED NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND APPLICATIONS OF ANTITUMOR THEREOF

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专利权人:

Zhejiang University

发明人:

DONG, Xiaowu,YANG, Bo,LI, Jia,ZHAN, Wenhu,WENG, Qinjie,ZHOU, Yubo,HU, Yongzhou,XU, Lei,LIU, Tao,HE, Qiaojun

申请号：

EP15769858

公开号：

EP3124486A4

申请日:

2015.03.21

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Disclosed are new substituted nitrogen-containing heterocyclic derivatives represented by formula (I) as AKT inhibitors, optical isomers, pharmaceutically acceptable salts or solvates thereof, wherein the definition of R1, R2, R3, R4, R5, R6, ring A, ring C, B, Q, Y, Z and m is shown in the description for details. In addition, medicaments comprising the derivatives as active components are also disclosed, which can be useful for treating proliferative diseases, such as cancer and inflammation, especially diseases relating to AKT kinase.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/