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新穎之八氫吡啶并喹唑啉衍生物、含有其之醫藥組成物及該等之用途
专利权人:
发明人:
NISHIMURA, TOSHIHIRO,西村俊洋,西村俊洋,UENO, YASUNORI,上野康德,上野康德,KASAI, KIYOSHI,河西洁,河西潔,YOSHIDA, MASAKO,吉田正子,吉田正子
申请号:
TW102145341
公开号:
TW201429968A
申请日:
2013.12.10
申请国别(地区):
TW
年份:
2014
代理人:
摘要:
To provide a novel compound that exhibits an agonistic effect on dopamine D2 receptors. A compound that can be represented by general formula (I) (in which R1 represents a C1-6 alkyl or the like R2 represents hydrogen or the like R3 and R4 each represent either hydrogen, a C1-6 alkyl, a R10R11N-C1-6 alkyl, an aralkyl, or the like R5 and R6 each represent hydrogen or the like and R7 represents hydrogen or the like) or a pharmacologically permitted salt thereof is provided, as are a pharmaceutical composition containing same and uses for said compound/salt and composition. This compound exhibits a superb stimulatory effect on dopamine D2 receptors and thus is useful as a therapeutic or prophylactic agent for Parkinsons disease and the like.本發明之課題在於提供一種具有多巴胺D2受體促效劑作用之新穎化合物。本發明係提供以一般式(I)所示之化合物或其藥理學上所容許之鹽、含有其之醫藥組成物及該等之用途。本發明之化合物由於具有優越之多巴胺D2受體刺激作用,故可用於作為帕金森氏病等之治療或預防劑。[式中,R1為C1-6烷基等;R2為氫等;R3及R4分別為氫、C1-6烷基、R10R11N-C1-6烷基、芳烷基等;R5及R6為氫等;R7為氫等]。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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