Substituted indole derivatives of formula (I)wherein the radicals have e. g. the following meaning: R1 is hydrogen, -C1-6-alkyl, R2 is hydrogen, -C1-6-alkyl or cycloC3-12-alkyl R3 is -OR R4 is hydrogen or halogen R5 is hydrogen, -C1-6-alkyl R6 is hydrogen, -C1-6-alkyl R is hydrogen or -C1-6-alkyl X is a group -C(O)CH2- or -CH=CH- R7 is hydrogen are potent inhibitors of Abeta peptide polymerization and can be used for the treatment of e.g. Alzheimers disease or ocular disorders.式(I)所示之經取代的吲哚衍生物:其中基團具有例如下列的定義:R1 是氫、-C1-6-烷基;R2 是氫、-C1-6-烷基或環C3-12-烷基;R3 是-OR;R4 是氫或鹵素;R5 是氫、-C1-6-烷基;R6 是氫、-C1-6-烷基;R 是氫或-C1-6-烷基;X 是基團-C(O)CH2-或-CH=CH-;R7 是氫;為Aβ胜肽的聚合作用之有效抑制劑,且其可用於治療例如阿滋海默症或眼的失調症。
