The present invention relates to a compound of the general formula (III) or a salt, solvate or prodrug thereof, as well as medical uses involving them, wherein A1 is selected from the group consisting of N and C-R8； A2 is selected from the group consisting of N and C-R3； A3 is selected from the group consisting of N and C-R9； A4 and A5 and A6 are independently selected from the group consisting of N and C-R1； R1 is selected from the group consisting of hydrogen, (C1-C3)alkyl, halogen, (C1-C3)alkoxy and (C1-C3)haloalkyl； R2 is selected from the group consisting of hydrogen, halogen and (C1-C3)alkyl； R3 is selected from the group consisting of hydrogen, (C1-C3)alkyl, NR4R5, (C1-C3)alkyl-NR4R5 and cyano； wherein R4 and R5 are independently selected from the group consisting of hydrogen, (C3-C5)cycloalkyl, (C3-C5)heterocycloalkyl, (C1-C3)alkyl, or R4 and R5 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring optionally comprising in addition to the aforementioned nitrogen atom a further heteroatom group selected from the group consisting of O and NR6, wherein R6 is selected from the group consisting of hydrogen, methyl, acetyl and formyl； Y is selected from the group consisting of O and S； R7 is selected from the group consisting of hydrogen, and (C1-C3)alkyl； R8 is selected from the group consisting of (C1-C4)alkyl, (C3-C5)cycloalkyl, and (C3-C5)heterocycloalkyl； and R9 is selected from the group consisting of hydrogen, (C1-C3)alkyl, (C1-C3)alkoxy, and methods for producing such compounds.本發明涉及一種具有通式(III)之化合物或其鹽、溶劑化物或前藥，連同它們參與的醫學用途，其中A1選自由以下各項組成之群組：N和C-R8；A2選自由以下各項組成之群組：N和C-R3；A3選自由以下各項組成之群組：N和C-R9；A4和A5和A6獨立地選自由以下各項組成之群組：N和C-R1；R1選自由以下各項組成之群組：氫、(C1-C3)烷基、鹵素、(C1-C3)烷氧基以及(C1-C3)鹵代烷基；R2選自由以下各項組成之群組：氫、鹵素以及(C1-C3)烷基；R3選自由以下各項組成之群組：氫、(C1-C3)烷基、NR4R5、(C1-C3)烷基-NR4R5以及氰基；其中R4和R5獨立地選自由以下各項組成之群組：氫、(C3-C5)環烷基、(C3-C5)雜環烷基、(C1-C3)烷基，或者R4和R5與它們所附接的氮原子一起形成5員至7員雜環，該雜環除前述氮原子之外，還視情況包括另外的雜原子基團，該基團選自由以下各項組成之群組：O和NR6，其中R6選自由以下各項組成
