OXYSTEROLS THAT ACTIVATE LIVER X RECEPTOR SIGNALING AND INHIBIT HEDGEHOG SIGNALING

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专利权人:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人:

Farhad PARHAMI,Michael JUNG,Khanhlinh NGUYEN,Dongwon YOO,William MATSUI

申请号：

US14945133

公开号：

US20160206631A1

申请日:

2015.11.18

申请国别(地区):

US

年份:

2016

代理人:

摘要：

This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.

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