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A NEW CONNECTION WITH THE EFFECTS OF THROMBOLYSIS, ACCEPTATION OF FREE RADICALS AND DIRECTED ACTION ON THE Trombus, AND ALSO WAY OF ITS PRODUCTION AND APPLICATION
专利权人:
ЛТД. (CN);ШАНХАЙ ЛУМОЗА ТЕРАПЬЮТИКС КО.
发明人:
ПЕНГ Шикуи (CN),ЖАО Минг (CN),ДЖИАНГ Ксуеюн (CN)
申请号:
RU2015112025
公开号:
RU2015112025A
申请日:
2013.03.15
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A three-component conjugate consisting of imidazoline, characterized by the ability to accept the free radicals of NO, a peptide characterized by thrombolytic activity, an peptide with a targeted effect on a blood clot, which are linked together by a suitable linking link. 2. The three-component conjugate according to claim 1, represented by formula I: in which NN is imidazoline, characterized by the ability to accept NO free radicals; AA is a linker containing at least three groups for binding; AA is a peptide characterized by thrombolytic activity; and AA is a peptide with a targeted action on a blood clot. 3. The three-component conjugate according to claim 1 or 2, wherein the imidazoline, characterized by the ability to accept NO free radicals, is 1,3-dioxo-2 - [(4-hydroxyacetoxy) phenyl] -4,4,5,5-tetramethylimidazoline. 4 . A ternary conjugate according to claim 1 or 2, wherein the linking groups are selected from the group consisting of a carboxyl group and an amino group. The three-component conjugate according to claim 4, wherein the linker is a natural amino acid, in particular L-Lys, L-Asp or L-Glu. The three-component conjugate according to claim 1 or 2, wherein the peptide characterized by thrombolytic activity is an oligopeptide containing a PAK sequence (Pro-Ala-Lys), an AKP sequence (Ala-Lys-Pro) or a CAR sequence (Lys-Ala-Pro) or a peptide containing repeating elements of a PAK sequence, an AKP sequence, or a CAR sequence. 7. The three-component conjugate according to claim 1 or 2, where the peptide with a directed effect on a blood clot is an oligopeptide containing1. Трехкомпонентный конъюгат, состоящий изимидазолина, характеризующегося способностью к акцептированию свободных радикалов NO,пептида, характеризующегося тромболитической активностью, ипептида с направленным действием на тромб,которые связаны вместе посредством подходящего связующего звена.2. Трехкомпонентный конъюгат по п. 1, представленный формулой I:,в которой NN представляет собой
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