Centre National de la Recherche Scientifique (CNRS);Universite Paris-Sud;ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS
发明人:
申请号:
EP17305257.2
公开号:
EP3372587A1
申请日:
2017.03.09
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present application relates to novel 3-imidazolines of formula (I') and (I) below:Wherein Ar1, Ar2, Ar3, and R1 to R6 are as defined in the claims. The 3-imidazolines of the invention are useful in antibiotic therapies, in particular as inhibitors of carbapenemases. They are also useful as antibiotics themselves. The present invention also concerns a method for preparing more specifically the 3-imidazolines of formula (I). The present invention further relates to conjugates of said compounds with known antibiotics.