ШЕНЛЕР Стюарт Д. (US),ПОВАЛА Кристофер (US),БРАУН Марк Барри (GB),ЛИМ Сиан Тионг (GB),ГРИНЭВЭЙ ЭВАНС Чарльз Родни (GB)
申请号：
RU2014104559/15
公开号：
RU2014104559A
申请日:
2012.07.12
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A composition that contains an imidazoline alpha agonist and a pharmaceutically acceptable excipient, wherein the composition is a gel. The composition according to p. 1, characterized in that the imidazoline alpha agonist is selected from anlinidine, antazoline, apraclonidine, brimonidine, BRL-44408, chloroethylclonidine, cybenzoline, cirazolin, clonidine, dihydroimidazole-2-ylidene, efenobenone-9fenoxane-efaroxane-efaroxane-13-phenoxane , phenoxazoline, idazoxane, imazapyr, imidacloprid, imidazole-4-one-5-propionic acid, imiloxane, indanidine, lofexidine, lysidine, mazindole, methiamide, methisoline, moxonidine, naphazoline, nepicastatin, (R) -3-nitroben, nitrophilin, natroben, nitroplin-3-nitroben oxymetazoline, romifidine, phentolamine, tetrahydra ozolin, thiamenidine, tizanidine, tolazoline, tolonidine, tramazolin, thymazoline and xylometazoline or a pharmaceutically acceptable salt thereof. 3. A composition according to claim 1, wherein the imazoline alpha agonist is oxymetazoline or a pharmaceutically acceptable salt thereof. The composition according to claim 1, characterized in that the composition contains a therapeutically effective amount of an imidazoline alpha agonist. The composition of claim 1, further comprising a gelling agent. The composition according to claim 1, further containing auxiliary additives selected from the group consisting of preservatives, solvents, emulsifiers, emulsion stabilizers, pH regulators, chelating agents, viscosity modifiers, antioxidants, surfactants, emollients, opacifiers , substances for optimizing the functioning conditions of the skin, buffers and their combinations. 7. The composition according to p. 1, characterized in that the composition has a pH level of approximately1. Состав, который содержит имидазолиновый альфа агонист и фармацевтически приемлемый наполнитель, причем состав является гелем.2. Состав по п. 1, отличающийся тем, что имидазолиновый альфа агонист выбран из анлинидина, антазолина, апраклонидина
