CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE PARIS-SUD;ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
发明人:
CARIOU, KEVIN,DODD, ROBERT H.,ROMERO, EUGENIE,BENCHEKROUN, MOHAMED,IORGA, BOGDAN,NAAS, THIERRY,OUESLATI, SAOUSSEN
申请号：
CA3055471
公开号：
CA3055471A1
申请日:
2018.03.08
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present application relates tonovel 3-imidazolinesof formula (I')and (I)below: (I') (I) Wherein Ar1, Ar2, Ar3, and R1 to R6 are as defined in the claims. The 3-imidazolines of the invention are useful in antibiotic therapies, in particular as inhibitors of carbapenemases. They are also useful as antibiotics themselves. The present invention also concerns a method for preparing more specifically the 3-imidazolines of formula (I). The present invention further relates to conjugates of said compounds with known antibiotics.
