NATIONAL RESEARCH COUNCIL OF CANADA;NATIONAL HEALTH RESEARCH INSTITUTES
发明人:
LENG, CHIH-HSIANG,CHEN, WANGXUE,CHONG, PELE
申请号：
CA3008042
公开号：
CA3008042A1
申请日:
2016.12.09
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
There are provided compositions and methods for prevention or treatment of Streptococcus pneumoniae (SP)-associated diseases. More specifically, there are provided recombinant lipidated fusion proteins comprising pneumococcal surface antigen A (PsaA), the recombinant lipidated fusion proteins comprising, from N-terminus to C-terminus, the N-terminal native lipid signal peptide of PsaA and the C-terminal structural gene for PsaA. Methods of inducing broad spectrum mucosal immunity against SP comprising administering a vaccine comprising recombinant lipidated fusion proteins are also described.
