National Research Council of Canada;National Health Research Institutes
发明人:
申请号：
EP16871875.7
公开号：
EP3387006A4
申请日:
2016.12.09
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
There are provided compositions and methods for prevention or treatment of Streptococcus pneumoniae (SP)-associated diseases. More specifically, there are provided recombinant lipidated fusion proteins comprising pneumococcal surface antigen A (PsaA), the recombinant lipidated fusion proteins comprising, from N-terminus to C-terminus, the N-terminal native lipid signal peptide of PsaA and the C-terminal structural gene for PsaA. Methods of inducing broad spectrum mucosal immunity against SP comprising administering a vaccine comprising recombinant lipidated fusion proteins are also described.
