NATIONAL RESEARCH COUNCIL OF CANADA;NATIONAL HEALTH RESEARCH INSTITUTES
发明人:
Chih-Hsiang Leng,Wangxue Chen,Pele Chong
申请号：
US15619075
公开号：
US10406221B2
申请日:
2017.06.09
申请国别(地区):
US
年份:
2019
代理人:
摘要：
There are provided compositions and methods for prevention or treatment of Streptococcus pneumoniae (SP)-associated diseases. More specifically, there are provided recombinant lipidated fusion proteins comprising pneumococcal surface antigen A (PsaA), the recombinant lipidated fusion proteins comprising, from N-terminus to C-terminus, the N-terminal native lipid signal peptide of PsaA and the C-terminal structural gene for PsaA. Methods of inducing broad spectrum mucosal immunity against SP comprising administering a vaccine comprising recombinant lipidated fusion proteins are also described.
