The present invention relates to a composition for alcohol metabolism and hepatoprotection and preparing method thereof, wherein the composition comprises an extracted mixture and a turmeric aqueous dispersion. The extracted mixture is derived from extracting an herb mixture comprising Puerariae Radix, Raisin tree, dried tangerine peel, Chinese wolfberry, licorice, Ophiopogonis Radix, Chrysanthemum, Cassiae Semen, honeysuckle, mulberry leaf, bamboo leaf, peppermint, Gardeniae Fructus, yeast powder, Bupleuri Radix, and Ampelopsis Brevipedunculata.本發明係有關於一種解酒護肝之組成物及其製備方法,該組成物包括:一萃取混合溶液以及一薑黃水分散液,該萃取混合溶液係由一藥材混合物經萃取而得,該藥材混合物包含葛根、拐棗、陳皮、枸杞子、甘草、麥冬、菊花、決明子、金銀花、桑葉、竹葉、薄荷、梔子、酵母粉、柴胡、以及山葡萄。