A compound of formula (I) or a pharmaceutically acceptable salt or solvate of said compound or tautomer, wherein (a) Y is a direct bond, and R3 is selected from aryl, (C1-C6) alkyl and (C1-) alkylene C4) -O-(C1-C4) alkyl； or (b) Y is (C1-4) alkylene, and R3 is selected from aryl, cycloalkyl (C3-C7) and a 3-10 membered heterocyclyl； Z is an oxygen or is absent； R1 is selected from H, halogen, OH, CN, (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-C6) alkoxy, -NHSO2R6, -NR6R7, -C (O) R6, -CO2R6, - C (O) NR6R7, -C (O) NR6SO2R8, 3 to 10 membered aryl and heterocyclyl； R2 is selected from H, halogen, OH, (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-C6) alkoxy, -NR6R7, -CO2R6, -C (O) NR6R7, -C (O) NR6SO2R8 , and 3 to 10 membered heterocyclyl； or R1 and R2 can be joined to form an alkylene (C2-C5) type bond, said union optionally incorporating 1 or 2 heteroatoms each independently selected from N, O and S； R5 is absent and R4 is selected from H, cycloalkyl (C3-C7), aryl, - (CH2) aryl, -C (O) R9, -CO2R9, -alkylene (C1-C6) - OC (O) R9, - alkylene (C1-C6) -O-CO2R9), -C (O) NR9R10, -alkylene (C1-C6) -OC (O) NR9R10 and -alkylene (C1-C6) -OP (O) (OH) 2； or R4 is absent and R5 is selected from R9, -C (O) R9, -CO2R9, -alkylene (C1-C6) -OC (O) R9, -alkylene (C1-C6) -OCO2R 9, -C (O ) NR9R10, -alkylene (C1-C6) -OC (O) NR9R10 and -alkylene (C1-C6) -OP (O) (OH) 2； each of R6 and R7 is independently selected from H, (C1-C6) alkyl, cycloalkyl (C3-C7), and -alkylene (C1-C6) cycloalkyl (C3-C7)； or R6 and R7 taken together with the nitrogen to which they are attached form a 3 to 6 membered saturated heterocycle optionally containing one or two additional heteroatoms selected from N, O and S； R8 is selected from (C1-C6) alkyl, (C3-C7) cycloalkyl and phenyl； each of R9 and R10 is independently selected from H, (C1-C6) alkyl, (C3-C7) cycloalkyl, aryl, - (CH2) aryl and 3-10 membered heterocyclyl； or R9 and R10, taken together with the nitrogen to which they are attached, form a 3-10 membered heterocyclyl gro
