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Retinoid-related orphan gamma receptor modulators (ROR-gamma) for use in the treatment of autoimmune and inflammatory diseases
专利权人:
Glaxo Group Limited
发明人:
HAN, Fangbin,LEI, Hui,LIN, Xichen,MENG, Qinghua,WANG, Yonghui
申请号:
ES13799318
公开号:
ES2626390T3
申请日:
2013.12.05
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of the formula I or a pharmaceutically acceptable salt thereof ** Formula ** wherein: R 1 is: - C 1 -C 6 alkyl; - methyl substituted with i) C3-C5 cycloalkyl; ii) phenoxy; or iii) a phenyl and a second substituent selected from the group consisting of: methyl, halo and methoxy; - ethyl substituted with i) phenyl, said phenyl is optionally substituted with halo or methoxy or ii) heteroaryl; - benzyl, wherein the phenyl group of said benzyl is optionally substituted with halo, methoxy or SO2CH2CH3; - C2 alkenyl optionally substituted with an F and a phenyl; - C3-C7 cycloalkyl, said cycloalkyl is optionally substituted with one or two substituents selected from the group consisting of phenyl, methyl and F; or said cycloalkyl is optionally fused with a phenyl ring; - heterocycloalkyl optionally substituted with one or two C1-C3 alkyls; - heteroaryl optionally substituted with one to two substituents selected from the group consisting of: C1-C3 alkyl, C1-C3 alkoxy and CF3; and - phenyl substituted with one to three substituents selected from the group consisting of: i) halo; ii) CN; iii) C1-C3 alkyl optionally substituted with one to three F; iv) C1-C3 alkoxy; v) (CH2) nNRaRb; vi) C (O) CH3; and vii) CH2OCH3; R2 is halo or C1-C3 alkyl; R3 is halo or methyl; R4 is H or methyl; R5 is C1-C3 alkyl; R6 is C1-C3 alkyl; R7 is selected from the group consisting of: - C1-C7 alkyl optionally substituted with one or more substituents selected from the group consisting of halo, C3-C5 cycloalkyl and CF3; - C3-C7 cycloalkyl optionally substituted with one or two substituents selected from the group consisting of F, CH2F, CHF2, methyl and methoxy, each k is 0 or 1; each p is 0 or 1; each n is 0, 1 or 2; each Ra is H or C1-C3 alkyl; each Rb is H or C1-C3 alkyl;Un compuesto de la fórmula I o una de sus sales farmacéuticamente aceptables**Fórmula** en donde: R1 es: - alquilo C1-C6; - metilo sustituido con i) cicloalquilo C3-C5; ii) fenoxi; o iii) un fenilo y un segundo sustituy
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