JESSIMAN, ALAN STUART,JOHNSON, PATRICK STEPHEN,MAANSSON, KRISTOFFER,SORENSEN, MORTEN DAHL
申请号：
CA3030370
公开号：
CA3030370A1
申请日:
2017.07.11
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to a compound according to general formula (I) wherein X represents N or CH； R1 is -CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl- (C1-C4)alkyl； R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl； R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl； R4 is (C1-C4)alkyl or (C1-C4)haloalkyl； R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or -ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.
