N-[(6-AZABICYCLO[3.2.1]OCT-1-YL)- ARYL-METHYL]-BENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
- 专利权人:
- 发明人:
- DARGAZANLI GIHAD,ESTENNE BOUHTOU GENEVIÈVE,MEDAISKO FLORENCE
- 申请号：
- IN3181/KOLNP/2011
- 公开号：
- IN2011KN03181A
- 申请日:
- 2011.07.27
- 申请国别(地区):
- IN
- 年份:
- 2012
- 代理人:
- 摘要：
The invention relates to N-[(6-azabicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide derivatives of the general formula (I) where: R is a hydrogen atom or a (C1-C6)alkyl group, (C3-C7)-cycloalkyl, optionally substituted by one or more fluorine, (C3-C7)-cycloalkyl, (C2-C4)alkenyl, phenyl, (C1-C6)alkoxy, hydroxy R2 is phenyl or naphtyl optionally substituted by one or more halogen, (C1-C6)alkyl, (C1-C6)alkoxy, halo-(C1C6)alkyl, NR4R5, (C1-C6)alkylthio, (C1-C6)alkyl-SO2, phenyl or heteroaryl, R2 is one or more hydrogen or halogen atom, halo-(C1-C6)alkyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)alkyl R3, R4 and R5 are independently a hydrogen atom or a (C1-C6)alkyl group R6 is a (C1-C6)alkyl group R4 and R5 may form together a ring selected from azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine, piperazine, azepine, optionally substituted by a (C1-C6)alkyl group. The invention also relates to the therapeutic use thereof and to a method for synthesizing same.
[WO2010092287A1]
- 来源网站：
- 中国工程科技知识中心
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