Granules were prepared using herbal extract in a state in which powdered by SOLVED drying, natural product-derived materials natural products extract or the like herbal extracts, formulations such as tablets, originally designed as a basic component decoction etc. Despite the fact that, in which decay time is long, the behavior in the body after administration is significantly different from the patient, etc. decoction poor dissolution properties. To 100 parts by weight [SOLUTION] special calcium silicate, and stirred with solid content of the natural product-derived substance dispersed liquid or advance, the aqueous solution containing an organic solvent or water such that 50 to 800 parts by weight method for producing a granulate which is characterized in that it is mixed and dispersed uniformly, and stir until the granulation bulk density 0.3~0.8g / ml loose. None [Selection Figure]【課題】乾燥して粉末化した状態の漢方エキス、生薬エキスあるいは天然物抽出エキス等の天然物由来物質を用いて製造した顆粒、錠剤等の製剤は、本来、煎じ薬等を基本成分として設計されているにもかかわらず、崩壊時間が長く、溶出性に劣り患者が服用後の体内における挙動が煎じ薬等と大きく異なるものである。【解決手段】特殊ケイ酸カルシウム100重量部に、予め液体もしくは、水または有機溶媒を含む水溶液に分散させた天然物由来物質の固形分が50~800重量部となるように加えて攪拌して均一に混合・分散させ、ゆるみ嵩密度0.3~0.8g/mlとなるまで攪拌造粒することを特徴とする顆粒物の製造方法。【選択図】 なし
