PROBLEM TO BE SOLVED: To provide a medicine or food or drink which has an osteoclast differentiation inhibitory action and an osteoblast differentiation promoting action and is useful for the regulation of bone and tooth metabolism. SOLUTION: Osteoclast differentiation inhibitor, osteoblast differentiation promoter, bone resorption inhibitor, bone formation promoter, bone metabolism regulator, bone-reducing disease containing an lignan compound derived from a pepper family plant as an active ingredient. Prophylactic and / or therapeutic agent. [Selection diagram] None【課題】 破骨細胞分化抑制作用と骨芽細胞分化促進作用を有し、骨と歯の代謝の調節に有用な医薬や飲食物の提供。【解決手段】 コショウ科植物由来リグナン化合物を有効成分として含有する、破骨細胞分化抑制剤、骨芽細胞分化促進剤、骨吸収抑制剤、骨形成促進剤、骨代謝調節剤、骨減少性疾患の予防及び／又は治療剤。【選択図】なし
