To provide an agent, and food and drink having an osteoclast differentiation inhibitory action and an osteoblast differentiation promoting action and useful for regulating bone and tooth metabolism.SOLUTION: The present invention provides an osteoclast differentiation inhibitor, an osteoblast differentiation promoter, a bone resorption inhibitor, a bone formation promoter, a bone metabolism regulator, and an agent for preventing and/or treating osteopenic disease, each of which contains artepillin C, or baccharin, or drupanin as an active ingredient.SELECTED DRAWING: None【課題】 破骨細胞分化抑制作用と骨芽細胞分化促進作用を有し、骨と歯の代謝の調節に有用な薬剤や飲食物の提供。【解決手段】 アルテピリンC、又はバッカリン、又はドルパニンを有効成分として含有する、破骨細胞分化抑制剤、骨芽細胞分化促進剤、骨吸収抑制剤、骨形成促進剤、骨代謝調節剤、骨減少性疾患の予防及び／又は治療剤。【選択図】なし
