MCL-1抑制劑及其使用方法农业专利-农业学术服务平台

发明人:: HIRD, ALEXANDER,赫德　亚力山德,赫德　亞力山德,BELMONTE, MATTHEW ALAN,贝尔蒙特　马修　艾伦,貝爾蒙特　馬修　艾倫,YANG, WENZHAN,杨　文章,楊　文章,SECRIST, JOHN PAUL,西奎斯特　约翰　保罗,西奎斯特　約翰　保羅,ROBBINS, DANIEL WILLIAM,罗宾斯　丹尼尔　威廉,羅賓斯　丹尼爾　威廉,KAZMIRSKI, S,赫德亚力山德,赫德亞力山德,贝尔蒙特马修艾伦,貝爾蒙特馬修艾倫,杨文章,楊文章,西奎斯特约翰保罗,西奎斯特約翰保羅,罗宾斯丹尼尔威廉,羅賓斯丹尼爾威廉

摘要：: Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazahepta cyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I)and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazahepta cyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,2 0,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.揭露了一種化合物，該化合物係17-氯-5,13,14,22-四甲基-28-氧雜-2,9-二硫雜-5,6,12,13,22-戊氮雜庚環[27.7.1.14,7.011,15.016,21.020,24.030,35]三十八碳-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-十三烯-23-甲酸(化學式I)及其鏡像異構物和藥學上可接受的鹽。還揭露了17-氯-5,13,14,22-四甲基-28-氧雜-2,9-二硫雜-5,6,12,13,22-戊氮雜庚環[27.7.1.14,7.011,15.016,21.020,24.030,35]三十八碳-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-十三烯-23-甲酸的醫藥組成物及其鏡像異構物和藥學上可接受的鹽，以及用此類化合物和組成物治療癌症的方法。