Disclosed are methods of treating cancer comprising administering 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo [27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, a pharmaceutically acceptable salt thereof; and acalabrutinib, or a pharmaceutically acceptable salt thereof.揭露了治療癌症之方法,該方法包括給予17-氯-5,13,14,22-四甲基-28-氧雜-2,9-二硫雜-5,6,12,13,22-戊氮雜庚環[27.7.1.14,7.011,15.016,21.020,24.030,35]三十八碳-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-十三烯-23-甲酸(化合物A)或其藥學上可接受的鹽;和阿卡盧替尼或其藥學上可接受的鹽。