ALBERS, RONALD,AYALA, LETICIA,CLAREEN, STEVEN S.,DELGADO MEDEROS, MARIA M.,HILGRAF, ROBERT,HEGDE, SAYEE,KOIS, ADAM,PLANTEVIN-KRENITSKY, VERONIQUE,MCCARRICK, MEG,NADOLNY, LISA,PALANKI, MOORTHY,SAHASRAB
申请号：
ES10182984
公开号：
ES2497540T3
申请日:
2006.01.13
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound having the formula (I): ** Formula ** or a pharmaceutically acceptable salt or stereoisomer thereof, wherein: R 1 is substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted aryl, substituted C 3-10 cycloalkyl or unsubstituted, substituted or unsubstituted C3-10 heterocycle or substituted or unsubstituted C3-10 heteroaryl； R2 is H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted aryl, substituted or unsubstituted C3-10 cycloalkyl, substituted or unsubstituted C3-10 heterocycle or substituted or unsubstituted C3-10 heteroaryl； and R3 is aryl substituted with one or more halogens or C3-10 heteroaryl substituted with one or more halogens, wherein the C3-10 aryl or heteroaryl group is optionally substituted with one or more C1-C6 alkyl, hydroxyl, hydroxyalkyl, alkoxy groups , alkoxyalkyl, amino, alkylamino, carboxy, aminocarbonyl, cyano, acylamino, alkanesulfonylamino, tetrazolyl, triazolyl or imidazolyl, wherein the term "substituted" denotes substitution by any of the substituents described or by halogen； C1-6 alkyl； C2-6 alkenyl； C2-6 alkynyl； hydroxyl； C1-6 alkoxy； Not me； nitro； thiol； thioether； imine； cyano； amido； phosphonate； phosphine； carboxyl； thiocarbonyl； sulfonyl； sulfonamide； ketone； aldehyde； ester； oxygen (>； = O)； haloalkyl； B (OH) 2, cycloalkyl which may be monocyclic or polycyclic fused or not fused； heterocycloalkyl, which may be monocyclic or polycyclic fused or not fused； carbocyclic or heterocyclic, monocyclic or polycyclic fused or non-fused aryl； primary, secondary, or tertiary amino； O- C1-6 alkyl； O-aryl, aryl； C1-6 arylalkyl； CO2CH3； CONH2； OCH2CONH2； NH2； SO2NH2； OCHF2； CF3 or OCF3, for use in the treatment or prevention of a chronic inflammatory disease； acute or chronic organ transplant rejection； a cancer associated with BCR-ABL； a leukemia； a cancer caused by aberrations in apoptosis； a malignant disease of a patient who needs a bone marrow transplant； a myeloproliferative disorder； a my
