ALBERS, RONALD,AYALA, LETICIA,CLAREEN, STEVEN S.,DELGADO MEDEROS, MARIA M.,HILGRAF, ROBERT,HEDGE, SAYEE,HUGHES, KEVIN,KOIS, ADAM,PLANTEVIN-KRENITSKY, VERONIQUE,MCCARRICK, MEG,NADOLNY, LISA,PALANKI, MO
申请号：
ES09008136
公开号：
ES2448500T3
申请日:
2006.01.13
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound having the formula (I): or a pharmaceutically acceptable salt or stereoisomer thereof, wherein: R1 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted aryl, substituted or substituted C3-10 cycloalkyl, C3 heterocycle -10 substituted or unsubstituted or C3-10 substituted or unsubstituted heteroaryl； R2 is H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted aryl, substituted or unsubstituted C3-10 cycloalkyl, substituted or unsubstituted C3-10 heterocycle or substituted or unsubstituted C3-10 heteroaryl； and R3 is aryl substituted with one or more halogens or C3-10 heteroaryl substituted with one or more halogens, wherein the aryl or C3-10 heteroaryl group is optionally substituted with one or more C1-C6 alkyl, hydroxyl, hydroxyalkyl, alkoxy groups, alkoxyalkyl, amino, alkylamino, carboxy, aminocarbonyl, cyano, acylamino, alkanesulfonylamino, tetrazolyl, triazolyl or imidazolyl, wherein the term "substituted" denotes substitution by any of the substituents described or by halogen； C1-6 alkyl； C2-6 alkenyl； C2-6 alkynyl； hydroxyl； C1-6 alkoxy； Not me； nitro； thiol； thioether； imine； cyano； amido； phosphonate； phosphine； carboxyl； thiocarbonyl； sulfonyl； sulfonamide； ketone； aldehyde； ester； oxygen (>； = O)； haloalkyl； B (OH) 2, cycloalkyl which may be monocyclic or polycyclic fused or not fused； heterocycloalkyl, which can be monocyclic or polycyclic fused or not fused； carbocyclic or heterocyclic, monocyclic or polycyclic fused or non-fused aryl； primary, secondary, or tertiary amino； O- C1-6 alkyl； O-aryl, aryl； C1-6 arylalkyl； CO2CH3； CONH2； OCH2CONH2； NH2； SO2NH2； OCHF2； CF3 or OCF3. for use in the treatment or prevention of esophagitis, hepatitis, pancreatitis or nephritis.Un compuesto que tiene la fórmula (I): o una sal o esteroisómero farmacéuticamente aceptable del mismo, en donde: R1 es alquilo C1-6 sustituido o no sustituido, arilo sustituido o no sustituido, cicloalquilo C3-10 sustituido o nosustituido,
