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PYRIDINE DERIVATIVE SUBSTITUTED WITH HETEROCYCLE AND PHOSPHONOXYMETHYL GROUP AND ANTIFUNGAL AGENT CONTAINING THE SAME
专利权人:
发明人:
申请号:
EP08868067.3
公开号:
EP2223926B1
申请日:
2008.12.26
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention provides antifungal agents that have excellent antifungal action, and is also excellent in terms of its properties, particularly its solubility in water and its safety. According to the present invention, disclosed are compounds represented by the following formula (I):(wherein R1 represents a hydrogen atom, a halogen atom, an amino group, R11-NH-(wherein R11 represents a C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C1-6 alkoxy C1-6 alkyl group, or a C1-6 alkoxycarbonyl C1-6 alkyl group), R12-(CO)-NH- (wherein R12 represents a C1-6 alkyl group or a C1-6 alkoxy C1-6 alkyl group), a C1-6 alkyl group, a hydroxy C1-6 alkyl group, a cyano C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6 alkoxy C1-6 alkyl groupR2 represents a hydrogen atom, a C1-6 alkyl group, an amino group, or a di-C1-6 alkylamino groupone of X and Y represents a nitrogen atom, and the other represents a nitrogen atom or an oxygen atomring A represents a 5- or 6-member heteroaryl ring or a benzene ring, which may have one or two halogen atoms or C1-6 alkyl groupsZ represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, -CH2O- -OCH2-, -NH-, -CH2NH-, -NHCH2-, -CH2S-, or -SCH2-R3 represents a hydrogen atom or a halogen atom, or a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-member heteroaryl group, or a 5- or 6-member non-aromatic heterocyclic group, wherein these groups may have one or two substituents selected from a substituent group α andR4 represents a hydrogen atom or a halogen atom[substituent Group α]a halogen atom, a cyano group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxycarbonyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, and a C2-6 alkynyl group).
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