您的位置: 首页 > 农业专利 > 详情页

Pyridine derivatives substituted with heterocycles and γ-glutamylamino groups and antifungal agents containing them
专利权人:
エーザイ・アール・アンド・ディー・マネジメント株式会社
发明人:
田中 圭悟
申请号:
JP2010534715
公开号:
JPWO2010047120A1
申请日:
2009.10.22
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
The present invention provides an antifungal agent having an excellent antifungal action and excellent in physical properties, in particular, solubility in water and safety. According to the present invention, a compound represented by the following formula (I) or a salt thereof: [wherein R1 is a hydrogen atom, a halogen atom, an amino group, R11-NH- (R11 is a C1-6 alkyl group, A hydroxy C1-6 alkyl group, a C1-6 alkoxy C1-6 alkyl group, or a C1-6 alkoxycarbonyl C1-6 alkyl group.), R12- (CO) -NH- (R12 is a C1-6 alkyl group) Group or C1-6 alkoxy C1-6 alkyl group), C1-6 alkyl group, hydroxy C1-6 alkyl group, cyano C1-6 alkyl group, C1-6 alkoxy group, or C1-6 alkoxy C1-6 alkyl group R2 represents a group represented by the formula (II); one of X and Y represents a nitrogen atom, the other represents a nitrogen atom or an oxygen atom; ring A represents a halogen atom or C1- 5- or 6-membered heteroaryl optionally having 1 or 2 alkyl groups Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, —CH 2 O—, —OCH 2 —, —NH—, —CH 2 NH—, —NHCH 2 —, —CH 2 S—, Or —SCH 2 —; R 3 may have a hydrogen atom, a halogen atom, or one or two substituents each selected from substituent group α, C 1-6 alkyl group, C 3- 8 means a cycloalkyl group, a C6-10 aryl group, a 5 or 6 membered heteroaryl group, or a 5 or 6 membered non-aromatic heterocyclic group; R4 means a hydrogen atom or a halogen atom; R represents a hydrogen atom or a C1-6 alkyl group which may be substituted with a dimethylamino group. [Substituent group α] Halogen atom, cyano group, C1-6 alkyl group, C1-6 alkoxy group, C1-6 alkoxycarbonyl group, C3-8 cycloalkyl group, C2-6 alkenyl group, and C2-6 alkynyl group . ] Is disclosed. [Chemical 1]本発明は、優れた抗真菌作用を有し、物性、特に、水への溶解性、及び安全性の面でも優れた抗真菌剤を提供する。本発明によれば、下式(I)で表される化合物又はその塩;[式中、R1が、水素原子、ハロゲン原子、アミノ基、R11-NH-(R11が、C1-6アルキル基、ヒドロキシC1-6アルキル基、C1-6アルコキシC1-6アルキル基、又はC1-6アルコキシカルボニルC1-6アルキル基を意味する。)、R12-(CO)-NH-(R12が、C1-6アルキル基又はC1-6アルコキシC1-6アルキル基)、C1-6アルキル基
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充