CHAPPIE, Thomas Allen,HAYWARD, Matthew Merrill,PATEL, Nandini Chaturbhai,VERHOEST, Patrick Robert
申请号：
ES14705882
公开号：
ES2638850T3
申请日:
2014.02.06
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula Ia: ** (See formula) ** or a pharmaceutically acceptable salt thereof. wherein: b is represented by an integer selected from 0, 1, 2, or 3； each R2, if present, is represented by a substituent independently selected from the group consisting of fluorine, chlorine, cyano, methyl, trifluoromethyl, methylthio, methoxy, and trifluoromethoxy； R6 and R7 are each independently selected from the group consisting of hydrogen, (C1-C6) alkyl, - (CH2) m-cycloalkyl (C3-C10), and - (CH2) m-heteroaryl (from 5 to 10 members)； wherein said (C1C6) alkyl, (C3-C10) cycloalkyl, and heteroaryl (5 to 10 members) are optionally substituted with one to three substituents independently selected from the group consisting of halogen, (C1-C6 alkyl) ), halo (C1-C6) alkyl, (C1-C6) alkoxy, halo (C1-C6) alkoxy, (C1-C6) alkylthio, and cyano； or R6 and R7 taken together with the nitrogen to which they are attached form a heterocycloalkyl (4 to 6 members), in which up to three carbon atoms of said heterocycloalkyl are optionally substituted with a substituent independently selected from the group consisting of halogen, (C1-C6) alkyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkoxy, (C1-C6) alkylthio, -C (O) NR4R5, hydroxy, and cyano, in which R4 and R5 are independently selected from the group consisting of hydrogen and (C1-C6) alkyl, and m is represented by an integer selected from 0, 1, or 2.Un compuesto de fórmula Ia: **(Ver fórmula)** o una sal farmacéuticamente aceptable del mismo. en la que: b está representado por un número entero seleccionado de 0, 1, 2, o 3； cada R2, si está presente, está representado por un sustituyente seleccionado independientemente de entre el grupo que consiste en flúor, cloro, ciano, metilo, trifluorometilo, metiltio, metoxi, y trifluorometoxi； R6 y R7 se seleccionan cada uno independientemente de entre el grupo que consiste en hidrógeno, alquilo (C1- C6), -(CH2)m-cicloalquilo (C3-C10), y -(CH2)m-heteroarilo (de 5 a 10 miembros)； en el que
