Compuestos de 4,5,6,7-tetrahidroimidazo[4,5-c]piridina como inhibidores de SSAO

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专利权人:

PROXIMAGEN LIMITED

发明人:

OLIVER, KATHRYN,SAVORY, EDWARD,HIGGINBOTTOM, MICHAEL,HORGAN, ANNE VIET-ANH

申请号：

ES09783085

公开号：

ES2440279T3

申请日:

2009.09.16

申请国别(地区):

ES

年份:

2014

代理人:

摘要：

A compound of formula (I), or a salt, solvate, hydrate, geometrical isomer, tautomer, optical isomer or N-oxide pharmaceutically acceptable thereof, wherein: R1 is selected from: (a) hydrogen, (b) C1 -6, and (c) -NR4AR4B R2 is selected from: (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 haloalkyl, (d) hydroxy-C1-6 alkyl, (e) C1-6 alkoxy-C1-6alkyl , (f) C1-6 haloalkoxy C1-6 alkyl, (g) N (R4AR4B) -C1-6alkyl, (h) -C (O) NR4AR4B, and (i) -C (O) O- C1-6 alkyl R3 is selected from: (a) C1-6 alkyl, (b) halo-C1-6 alkyl, (c) hydroxy-C1-6 alkyl, (d) C1-6 alkoxy C1-6 alkyl, (e) halo C1-6 alkoxy-C1-6alkyl, (f) N (R4AR4B) -C1-6alkyl, (g) C6-10 aryl-C1-4 alkyl, (h) heteroaryl-C1-4 alkyl, (i) C6-10 aryloxy-C1-4 alkyl, (j) heteroaryloxy-C 1-4 alkyl, (k) C3-8 cycloalkyl, (l) C3-8cycloalkyl-C1-4alkyl, (m) heterocyclyl.Un compuesto de fórmula (I), o una sal, solvato, hidrato, isómero geométrico, tautómero, isómero óptico o N-óxido farmacéuticamente aceptable del mismo, en donde: R1 está seleccionado de: (a) hidrógeno, (b) alquilo C1-6, y (c) -NR4AR4B R2 está seleccionado de: (a) hidrógeno, (b) alquilo C1-6, (c) halo-alquilo C1-6, (d) hidroxi-alquilo C1-6, (e) alcoxi C1-6-alquilo C1-6, (f) halo-alcoxi C1-6-alquilo C1-6, (g) N(R4AR4B)-alquilo C1-6, (h) -C(O)NR4AR4B, y (i) -C(O)O-alquilo C1-6 R3 está seleccionado de: (a) alquilo C1-6, (b) halo-alquilo C1-6, (c) hidroxi-alquilo C1-6, (d) alcoxi C1-6-alquilo C1-6, (e) halo-alcoxi C1-6-alquilo C1-6, (f) N(R4AR4B)-alquilo C1-6, (g) aril C6-10-alquilo C1-4, (h) heteroaril-alquilo C1-4, (i) ariloxi C6-10-alquilo C1-4, (j) heteroariloxi-alquilo C1-4, (k) cicloalquilo C3-8, (l) cicloalquil C3-8-alquilo C1-4, (m) heterociclilo.

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