PROBLEM TO BE SOLVED: To provide a freeze-dried preparation of docetaxel having both inhibition of degradation of an active component and excellent storage stability, and to provide a method for producing the same.SOLUTION: The freeze-dried preparation of an oil-in-water emulsion contains: at least one taxane-based active component selected from docetaxel and a derivative thereof an oily component containing a medium chain fatty acid triglyceride in a ratio of 80 w/w% or more and 100 w/w% or less a surfactant containing a phospholipid in a ratio of 50 w/w% or more and 100 w/w% or less a fatty acid and an excipient.COPYRIGHT: (C)2013,JPO&INPIT【課題】活性成分の分解抑制と良好な保存安定性を兼ね備えたドセタキセルの凍結乾燥製剤及びその製造方法を提供する。【解決手段】ドセタキセル及びその誘導体から選択される少なくとも1種のタキサン系活性成分と、中鎖脂肪酸トリグリセリドを80w/w%を超え100w/w%以下の割合で含有する油性成分と、リン脂質を50w/w%以上100w/w%以下の割合で含有する界面活性剤成分と、脂肪酸と、賦形剤と、を含む水中油型乳化物の凍結乾燥製剤。【選択図】なし
