ELLA KRISHNA MURTHY,BRUNDA GANNERU,KUMAR HALMATHUR MAHABALARAO SAMPATH,SREEKANTH MIRYALA
申请号：
IN201847011475
公开号：
IN201847011475A
申请日:
2018.03.27
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
ABSTRACT NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof wherein Ri and Rboth are hydrogen or Ri is hydrogen and R2is alkyl or aryl or Ri is alkyl or aryl and R2 is hydrogen or Rx and R2 both are alkyl or aryl (same or different groups) wherein alkyl group constitute C1-C6 alkyl or higher (both linear and branched) with or without heteroatoms and aryl group constitute phenyl, substituted phenyl, heteraryl, arylalkyl and polynuclear aromatics. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants in vaccines.
