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NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE
专利权人:
MOTIDA FARMAS'JUTIKAL KO.; LTD.;MOTIDA FARMASJUTIKAL KO.
发明人:
OKANO Akikhiro (JP),ОКАНО Акихиро (JP),KOSUGA Naoto (JP),КОСУГА Наото (JP),OKhKOUTI Munetaka (JP),ОХКОУТИ Мунетака (JP),KhOTTA Daido (JP),ХОТТА Даидо (JP),MAKABE Muneesi (JP),МАКАБЕ Мунеёси (JP),OKANO AKIKHIRO,ОКАНО Акихиро,KOSUGA NAOTO,КОСУГА Наото,OKHKOUTI MUNETAKA,ОХКОУТИ Мунетака,KHOTTA DAIDO,ХОТТА Даидо,MAKABE MUNEESI,МАКАБЕ Мунеёси
申请号:
RU2012131840/04
公开号:
RU0002567755C2
申请日:
2010.12.24
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to compounds of formula,where n equals 1; p equals 0; j is an integer from 0 to 3; k is an integer from 0 to 2; A is a C6-14aryl group which includes phenyl, 2,3-dihydro-1H-indenyl, 6,7-dihydronaphthyl which is optionally substituted with 1-2 L, or a 6-10-member heterocyclic group which includes piperidinyl, 2,3,-dihydrobenzofuranyl, 3,4-dihydro-2H-chromenyl, which is optionally substituted with 1-5 L; ring B is a benzene ring; X is an oxygen atom or -NR7-; R1 is absent; R2 is a hydrogen atom; R3, R4, R5, R6 and R7 are independently a group randomly selected from a hydrogen atom and a C1-6alkyl group; L is independently a halogen atom, a C1-10alkyl group, which is optionally substituted with 1-5 RI substitutes, C1-10alkoxy group, which is optionally substituted with 1-5 RI substitutes, a phenyl group, which is optionally substituted with 1-5 RII substitutes, a 6-member heterocyclic group selected from pyridyl, pyrimidinyl, piperdinyl and 3,6-dihydro-2H-pyranyl, which is optionally substituted with 1-5 RII substitutes, phenoxy, pyridyloxy, which is optionally substituted with 1-5 RII substitutes, a non-aromatic heterocyclic oxy group selected from piperidinyloxy and oxanyloxy, which is optionally substituted with 1-5 RII substitutes, benzyloxy; Ra is a C1-6alkyl group; RI and RII substitutes are as indicated in claim 1 of the invention; or to pharmaceutically acceptable salts. The invention also relates to a pharmaceutical composition containing a compound of formula (I) and to intermediate compounds of formulafor producing compounds of formula (I).EFFECT: compounds of formula (I), having agonistic action on GPR40.29 cl, 22 tbl, 144 exИзобретение относится к соединениям формулы (I), где n является 1; p является 0; j представляет собой целое число от 0 до 3; k представляет собой целое число от 0 до 2; A представляет собой C6-14арильную группу, включающую фенил, 2,3-дигидро-1Н-инденил, 6,7-дигидронафтил, которая необязате
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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