The present relates to compounds of the formula (1), in which X is o or NH r1 is phenyl or pyridinyl, pirimidinilo, each of them is optionally replaced by 1, 2 or 3 Halogen c1-4 alkyl, R2 is H, or C1 - 4 haloalquilo, R3, R4 and R5 regardless of whether they are: H, alkyl C1 - 7, option Onalmente replaced by one or more halogeno, cyano or HydroxyC1 - alkoxy optionally substituted by one or more 7 NS, halogens, halogen, NO2, - C (o) - ra in ra is Hydroxy, alkoxy C1 C1 - 7 - 7 alkyl or phenyl, phenoxy, nrbrc, in which Independence between RB and RC are: Hydrogen, alkyl C1 - 7, - C (o) - C1 - 7 alkyl, optionally substituted by one or m S halogen -, - C (o) - (CH2) M or alkyl C1 - 7, where M is the number of 0, 1, 2, 3, 4, 5 or 6,- C (o) C (o) - C1 - 7 or alkyl, - C (o) CH2C (or C1 - 7) or alkyl, - C (o) RI, the RI is phenyl or heteroaryl 5 or 6 links, each of which is optionally substituted by one or more, and - C (O) - 7 pp. ISBN cycloalkyl, optionally substituted by one or more B, - C (o) - RII and RII is said heterociclilo 3 to 7 is Labones, optionally substituted by one or more heterociclilo, 3 to 7 links.Optionally substituted by one or more heteroaryl, 5 or 6 links, optionally substituted by one or more e - C (o) - in which nrdre, RD and re Independence between them are: C1 - 7 h, alkyl, optionally substituted by one or more Hydroxy, or halogeno, cyano, - T - (CH2) cycloalkyl option C3 - 7 Eventually replaced by one or more B and t is the Number 0, 1, 2, 3 or 4 - (CH2) or alkyl - or - C1 - 7Where U is the Number 2, 3, 4, 5 or 6, - (CH2) - heterociclilo X, where X is the Number 0, 1, 2, 3 or 4, and said heterociclilo is optionally substituted by one or more Rd and re together with nitrogen which are form a United whole heterociclilo optionally substituted by one or more,Or R3 together with the nitrogen atom of an adjacent Aromatic Ring FUSED pyridazine hydrochloride 5 links with other two nitrogen Atoms of the ring, the FUSED ring is optionally substituted by alkyl
