OLIGO-ARN DOUBLE HELICE SPECIFIQUE DE L'AMPHIREGULINE, STRUCTURE EN DOUBLE HELICE D'OLIGO-ARN COMPRENANT LEDIT OLIGO-ARN DOUBLE HELICE ET COMPOSITION DESTINEE A PREVENIR OU TRAITER LES MALADIES RESPIRATOIRES EN CONTENANT
The present invention relates to an amphiregulin-specific double-helical oligo-RNA which is a high-efficiency amphiregulin expression inhibitor capable of being useful for preventing or treating respiratory diseases. In addition, the present invention relates to: an amphiregulin-specific double-helical oligo-RNA structure in which hydrophilic and hydrophobic materials are simple covalently bonded or linker-mediated covalently bonded to improve the in vivo stability and cell delivery efficiency of the amphiregulin-specific double-helical oligo-RNA； and nanoparticles comprising the same. The amphiregulin-specific double-helical oligo-RNA structure according to the present invention can improve the stability of the amphiregulin-specific double-helical oligo-RNA and effectively enhance the cell membrane transduction function thereof without deteriorating the function of the amphiregulin-specific double-helical oligo-RNA. Therefore, it is possible to effectively deliver the amphiregulin-specific double-helical oligo-RNA into cells even with a relatively low concentration of dosage by employing the amphiregulin-specific double-helical oligo-RNA structure, thereby enabling the helpful use thereof for preventing or treating respiratory diseases.
