Glen Robert Rennie,Rajesh R. Iyengar,Thomas Wai-Ho Lee,Takashi Nakai,Ara Mermerian,Lei Jia,G-Yoon Jamie Im,Paul Allan Renhowe,Joon Jung,Peter Germano,Karthik Iyer,Timothy Claude Barden,Kim Tang
申请号:
US16273557
公开号:
US20190248794A1
申请日:
2019.02.12
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I: