General Electric Company;Hammersmith Imanet Limited
发明人:
Padilla De Jesus, Omayra Liz,Glaser, Matthias Eberhard,Arstad, Erik,Syud, Faisal Ahmed,Kovacs, Ernest William
申请号：
AU2008340449
公开号：
AU2008340449B2
申请日:
2008.12.12
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Provided herein are methods for introducing flυorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive teminus and an azido/alkyne-reactive terminus； (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof； and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.
