The present invention relates to general formula (I) compound and salt and neurological progression derivative (seeing right figure) as medicine, wherein A is a non-aromatic ring system of containing 4-8 carbon atom, wherein said ring system comprises at least one two key, and the one or more carbon atoms in the ring can be substituted by the X group, and wherein X is selected from S, O, N, NR 4, SO, CO or SO 2D is O, S, SO 2, NR 4Or CH 2Z 1And Z 2Be O, S or NR independently of each other 5R 2Be H, OR 6Or NHR 7E is alkyl or cyclic hydrocarbon radical, and perhaps monocycle or polycyclic replace or unsubstituted ring system, and this ring system can contain one or more X groups and comprise at least one aromatic ring Y is that hydrogen, halogen, halo alkyl, halo alkyl oxygen base, alkyl, cyclic hydrocarbon radical, monocycle or polycyclic replace or unsubstituted ring system.
