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SYSTEM FOR IMPROVED DELIVERY OF GENE MODULATING COMPOUNDS
专利权人:
发明人:
申请号:
EP11756627.3
公开号:
EP2547367A1
申请日:
2011.03.15
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention relates to a system for intracellular cargo delivery comprising: D(n)BAC wherein: Component D is a amine-containing compound n is a number of amines between 2-6, Component B is a di-, tri or tetra ring system, such as quinoline or naphthalene derivatives which may contain several hetero atoms chosen from N, S, O and P Component A is an aliphatic linear or branched hydrophobic chain of at least 4 carbon atoms preferably an epoxide, alkyl halide or an acrylamide with 6-30 carbon atoms or a derivative thereof and Component C is an optional targeting moiety, such as homing peptide or aptamer, wherein components D, B, A and C may be coupled to each other via spacer(s). It also relates to the use of the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition, a material covered with the system and a material having the delivery systems within the material.
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