OMAYRA LIZ PADILLA DE JESUS,ERNEST WILLIAM KOVACS,MATTHIAS EBERHARD GLASER,ERIK ARSTAD,FAISAL AHMED SYUD
申请号：
IN3196/DELNP/2010
公开号：
IN2010DN03196A
申请日:
2010.05.06
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
(i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.
