Omayra Liz Padilla de Jesus,Faisal Ahmed Syud,Rong Zhang,Ernest William Kovacs
申请号：
US13032099
公开号：
US08487080B2
申请日:
2011.02.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reactive terminus and an aldehyde-reactive terminus (ii) reacting the thiol-reactive terminus of the linker with a polypeptide comprising at least one thiol group or a reactive derivative thereof and (iii) subsequently reacting the aldehyde-reactive terminus of the linker with a fluorine-substituted aldehyde.
