Arstad, Erik,Kovacs, Ernest William,Padilla De Jesus, Omayra Liz,Glaser, Matthias Eberhard,Syud, Faisal Ahmed
申请号：
AU2013204388
公开号：
AU2013204388A1
申请日:
2013.04.12
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013204388A120130509.pdf#####Documntm27-12 04/2013 ABSTRACT Provided herein are methods for introducing fluorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.
