A compound having the formula: ** Formula ** or geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof； where ------------ represents a single or double bond； m and q are independently selected from 0, 1 and 2； p is selected from 0, 1, 2 or 3； R1 is -C (O) OR21； R21 is alkyl, substituted alkyl, alkenyl or substituted alkenyl； R2 is selected from absent, hydrogen, halogen, -OR10, -SR10, -NR10R11-, optionally substituted aliphatic, optionally substituted aryl or optionally substituted heterocyclyl； r is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11； A is selected from absent, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, -S-, -O-, -S (O) -, -S (O) 2-, -S [C (R30) (R31 )] u-, -S (O) [C (R30) (R31)] u-, -S (O) 2 [C (R30) (R31)] u-, - O [C (R30) (R31) ] u-, -N (R30) -, - N (R30) [C (R31) (R32)] u-, - [C (R30) (R31)] u, -C (O) [C (R30) (R31)] u-； each u is independently 1, 2, 3, 4, 5, 6 or 7； D is selected from absent, -O-, -NR33, -C (R34) (R35) -, -S-, -S (O) -, -S (O) 2-, -C (O) -； Each R3, R4, R5, R30, R31, R32, R33, R34, and R35 is independently selected from absent, hydrogen, halogen, -OR10, -SR10, -NR10R11-, -C (O) R10, optionally substituted aliphatic, optionally substituted aryl or optionally substituted heterocyclyl； wherein each R10 and R11 is independently absent, hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl； alternatively, two R10 and R11 together with the atoms to which they are attached, can form an additional optionally substituted 3, 4, 5, 6 or 7 member ring； each G3 and G4 is independently selected from -N-； and X20 is -C (R10) - or -N-； wherein the term "substituted" refers to the replacement of one or more hydrogen radicals in a given structure with the radical of a specified substituent selected from: halo, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, thiol, alkylthio, arylthio, alkylthioalkyl , arylthioalkyl, alkylsulfonyl
