BELL, Andrew Simon,SCHREYER, Adrian Michael,VERSLUYS, Stéphanie
申请号：
EPEP2019/064450
公开号：
WO2019/233994A1
申请日:
2019.06.04
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The invention provides a compound of formula (I), or pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, (I) wherein R1 is an optionally substituted phenyl, or an optionally substituted 5-or 6-membered aromatic heterocycle comprising 1, 2 or 3 heteroatoms independently selected from the group consisting of N, S and O, wherein said phenyl is optionally substituted with 1, 2 or 3 substituents, each substituent being independently selected from the group consisting of halogen, OH, C1-8alkyl, C1-8alkyl substituted with 1, 2 or 3 halogens or OH groups, OC1-8alkyl, and OC1-8alkyl substituted with 1, 2 or 3 halogens or OH groups, and wherein said 5-or 6-membered aromatic heterocycle is optionally substituted with 1, 2 or 3 substituents, each substituent being independently selected from the group consisting of halogen, OH, C1-8alkyl, OC1-8alkyl substituted with 1, 2 or 3 halogens or OH groups, OC1-8alkyl, and OC1-8alkyl substituted with 1, 2 or 3 halogens or OH groups； and R2 is an optionally substituted 5-or 6-membered aromatic heterocycle comprising 2 or 3 heteroatoms independently selected from the group consisting of N, S and O, wherein said -or 6-membered aromatic heterocycle is optionally substituted with 1, 2 or 3 substituents, each substituent being independently selected from the group consisting of C1-3alkyl and C1-3alkyl substituted with 1, 2 or 3 halogens. The invention also provides pharmaceutical compositions comprising a compound of formula (I), and the use of compounds of formula (I) as medicaments, in particular in the treatment of cancer.L'invention concerne un composé de formule (I), ou un ester, un amide, un carbamate, un solvate ou un sel pharmaceutiquement acceptable de celui-ci, comprenant un sel d'un tel ester, amide ou carbamate, (I). Dans la formule, R1 représente un phényle éventuellement substitué, ou un hétérocycle aromatique à 5 ou 6 chaînons éventuellement substi
