BUTLER DAVID,JUNG MICHAEL E.,JAYARAMAN MUTHUSAMY,MANOHARAN MUTHIAH,RAJEEV KALLANTHOTTATHIL G.
申请号：
NZ59618610
公开号：
NZ596186A
申请日:
2010.05.05
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
NZ 596186 The disclosure relates to a composition comprising: a sterol, a neutral lipid, a PEG or PEG-modified lipid, and a lipid of formula (V) which contains a piperazine moietie, and optionally a targeting lipid comprising N-acetyl galactosamine as a targeting moiety. Also disclosed are methods of making compounds of formula (V). These lipid compositions are useful for therapeutic agent delivery of nucleic acids as well as nucleic acid-lipid particle compositions.
