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LIPID PARTICLE AND NUCLEIC ACID DELIVERY CARRIER
专利权人:
Fujifilm Corporation
发明人:
NISHIKAWA, Naoyuki,ONO, Makoto,SUGIYAMA, Susumu,IWAKI, Yoshihide
申请号:
EP15821518
公开号:
EP3170503A4
申请日:
2015.07.16
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
An object of the present invention is to provide lipid particles which have low cytotoxicity, can stably hold nucleic acid molecules outside cells, and can promptly release nucleic acids in cytoplasm after escaping from endosome, and a nucleic acid delivery carrier. According to the present invention, there are provided lipid particles containing a compound represented by the following General Formula (1), sterol, at least one lipid selected from the group consisting of a neutral lipid and a lipid having a polyethylene glycol chain, and nucleic acids, and a nucleic acid delivery carrier. In the formula, R 1 and R 2 are the same as or different from each other, and are alkyl groups having 10 to 22 carbon atoms.
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